About this Project
We are developing a Medicago Hapmap as part of an international consortium consisting of the University of Minnesota, the National Center for Genome Resources (NCGR), Boyce Thompson Institute (BTI), J. Craig Venter Institute (JCVI) Hamline University, the University of Southern California, INRA-Montpellier, ENSAT-Toulouse, and the Noble Foundation.
Briefly, 384 inbred lines spanning the range of Medicago diversity are being resequenced using Illumina next generation technology. This provides a foundation for discovering single nucleotide polymorphisms (SNPs), insertions/deletions (INDELs) and copy number variants (CNV) at very high resolution among the Medicago lines. Thirty of these lines have been deeply resequenced (20X coverage or more), while the remainder are sequenced at least 5X coverage. The resulting database of sequence variants establishes a basis for describing population structure and identifying genome segments with shared ancestry (haplotypes) - and thereby creating a long-term, community-accessible genome-wide association (GWA) mapping resource.
Primary funding for the Medicago Hapmap project comes from the Plant Genome Program of the National Science Foundation.
Updated SNPs against Mt4.0 now available.
Mt4.0 released by J. Craig Venter Institute.
Genome-wide association analysis of Medicago Hapmap published in PLoS ONE
Medicago genome sequence published in Nature and PNAS